Alice Wonder is a patient at the Radcliffe Lunatic Asylum after she killed her classmates. Everyone believes that Alice is insane, except for Professor Pillar, another patient in the asylum. The professor believes that Alice is the real Alice from Wonderland and she is meant to fight in the Wonderland Wars.
Professor Pillar is able to talk to the director of the Asylum, who allows Alice to leave the asylum and has Alice pose as a student at Oxford University. Alice is tasked with finding the serial killer, The Cheshire, however no one knows what he looks like in human form - all of the monsters from Wonderland have come back as modern day criminals.
While trying to stop The Cheshire, Alice meets Jack Diamonds who seems so familiar, he looks just like her dead boyfriend whom she killed. Alice and the Pillar travels from London to the Vatican in search of The Cheshire and to provide that Alice is sane.